GLP-1: a mediator of the beneficial metabolic effects of bariatric surgery?
نویسندگان
چکیده
There has been increasing interest in the role that gut hormones may play in contributing to the physiological changes produced by certain bariatric procedures, such as Roux-en-Y gastric bypass and sleeve gastrectomy. Here, we review the evidence implicating one such gut hormone, glucagon-like peptide-1, as a mediator of the metabolic benefits of these two procedures.
منابع مشابه
Gastrointestinal Hormones, Intestinal Microbiota and Metabolic Homeostasis in Obese Patients: Effect of Bariatric Surgery.
BACKGROUND/AIM Bariatric surgery has proven efficacy in the modulation of a number of gut peptides that can contribute to improvement of diabetes and its associated metabolic changes. In order to evaluate dietary intake, nutritional assessment and plasma levels of gastrointestinal peptides, we enrolled severely obese patients before and after bariatric surgery. PATIENTS AND METHODS We evaluat...
متن کاملCandidate Information
i. Ongoing research projects: 1) the beneficial metabolic effects of duodenal nutrient exclusion by barrier endolumenal sleeve, 2) FGF21 as a mediator of the chronic effects of glucagon receptor agonism, 3) Use of GLP-1R agonists to optimize bariatric surgery in a DIO rat model, and 4) Glucagon-receptor agonism stimulates insulin action in mice. i. Ongoing research projects: 1) the beneficial m...
متن کاملDiabetes, Neurodegenerative Diseases, GLP-1 & Surgery: Evidence Calls for Exploration
Discussion: Several links between diabetes, insulin resistance, metabolic syndrome and neurodegenerative diseases have been found. Factors such as GLP1 play a key role in Diabetes as well as in the development of neurodegenerative diseases. The proposed pathways suggested to explain the benefits of bariatric surgery on neurodegenerative diseases, involve the incretin pathways. Evidence gathered...
متن کاملThe effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones
Bariatric surgery for obesity has proved to be an extremely effective method of promoting long-term weight reduction with additional beneficial metabolic effects, such as improved glucose tolerance and remission of type 2 diabetes. A range of bariatric procedures are in common use, including gastric banding, sleeve gastrectomy and the Roux-en-Y gastric bypass. Although the mechanisms underlying...
متن کاملAn overview of glucagon-like peptide-1 receptor agonists for the treatment of metabolic syndrome: A drug repositioning
Metabolic syndrome (MetS) is a clustering of several cardiovascular risk factors that include: obesity, dyslipidemia, hypertension and high blood glucose, and often requires multidrug pharmacological interventions. The management of MetS therefore requires high healthcare cost, and can result in poor drug treatment compliance. Hence drug therapies that have pleiotropic beneficial effects may be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Physiology
دوره 30 1 شماره
صفحات -
تاریخ انتشار 2015